Pathophysiology of subarachnoid hemorrhage

Inflammation
Soluble vascular endothelial-cadherin (sVE-cadherin) are cleaved from VE-cadherin during inflammatory states. sVE-cadherin appears to activate microglia to increase production of iNO, IL-1β, reactive oxygen species, and increase their size and metabolic activity. High CSF levels of them are associated with worsened outcomes in SAH (mRS 3-6).