Anti-GAD65 antibody encephalitis

Signs and symptoms
A particular variant of this disorder is called progressive encephalomyelitis with rigidity and myoclonus (PERM), which has features of stiff-person syndrome but also with prominent brainstem features such as myoclonus, oculomotor disorders, and distrubances of respiratory rhythm. Patients also may have myelopathy, autonomic dysfunction, and encephalopathy.
 * Stiff-person syndrome
 * Cerebellar ataxia
 * Limbic encephalitis
 * Seizures
 * Myelopathy
 * Autonomic dysfunction
 * Myoclonus
 * Brainstem abnormalities
 * Palatal myoclonus
 * Abnormal eye movements
 * Abnormal respirations

Treatment
IVIG and steroids are used. Benzodiazepines may be useful for stiff person syndrome type features.