Neuroprotection in traumatic brain injury

Progesterone for Traumatic Brain Injury Experimental Clinical Treatment (PROTECT III, 2014)
This trial randomized 882 patients of a planned 1140 to progesterone vs placebo within 4 hours after severe TBI, and was stopped early due to futility. There were no differences in the number of patients with a favorable outcome, and phlebitis/thrombophlebitis was more frequent in the progesterone group.

Study of a Neuroprotective Agent, Progesterone, in Severe Traumatic Brain Injury (SYNAPSE, 2014)
This trial randomized 1195 patients with severe TBI to progesterone vs. placebo within 8 hours after severe TBI, and showed no difference in neurological outcomes or mortality, and no safety concerns.